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Title	en Impact of residual in situ carcinoma on postoperative survival in 125 patients with extrahepatic bile duct carcinoma
Creator	en Nakanishi, Yoshitsugu en Kondo, Satoshi NRID 1000030215454 en Zen, Yoh NRID 1000090377416 en Yonemori, Atsuya en Kubota, Kanako en Kawakami, Hiroshi NRID 1000080399823 en Tanaka, Eiichi NRID 1000060374279 en Hirano, Satoshi NRID 1000050322813 en Itoh, Tomoo NRID 1000020301880 en Nakanuma, Yasuni NRID 1000010115256
Accessrights	open access
Rights	en The original publication is available at www.springerlink.com
Subject	Other en carcinoma in situ Other en superficial spread Other en extrahepatic bile duct carcinoma Other en prognosis NDC 494
Description	Abstract en Purpose: The aim of this study was to determine the impact of the presence of carcinoma in situ at the bile duct stump on postoperative survival in patients who underwent resection of extrahepatic bile duct carcinoma. Methods: The patients with resected extrahepatic bile duct carcinoma were divided into three groups according to resected margin status: no evidence of residual carcinoma (Negative group, n=96); carcinoma in situ at the bile duct stump (CIS group, n=10); and invasive carcinoma at any surgical margin (Invasive group, n=19). Cause-specific survival for these groups was compared statistically. Results: Surgical margin status was identified as a prognostic factor on univariate analysis (p=0.005) and was an independent prognostic factor on multivariate analysis (p=0.018). The CIS group displayed significantly better survival than the Invasive group (p=0.006), and the survival was comparable to that for the Negative group (p=0.533). Two of three patients in the CIS group with local recurrence died >5 years after surgical resection. Conclusions: Patients with positive ductal margins of carcinoma in situ of the extrahepatic bile duct do not appear to show different survival after resection compared to patients with negative margins, but remnant carcinoma in situ is likely to develop late local recurrence.
Publisher	en Springer Japan
Date	Issued2010-03
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/48196
Relation	isVersionOf DOI https://doi.org/10.1007/s00534-009-0127-1 PMID 19521656
Journal	PISSN 1868-6974 EISSN 1868-6982 en Journal of Hepato-Biliary-Pancreatic Sciences Volume Number17 Issue Number2 Page Start166 Page End173
File	fulltext JHBPS17-2_166-173.pdf 197.97 KB (application/pdf) Issued2010-03
Oaidate	2023-07-26