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Title	en What is the appropriate size criterion for proton radiotherapy for hepatocellular carcinoma? A dosimetric comparison of spot-scanning proton therapy versus intensity-modulated radiation therapy
Creator	en Toramatsu, Chie en Katoh, Norio NRID 1000080572495 en Shimizu, Shinichi NRID 1000050463724 en Nihongi, Hideaki en Matsuura, Taeko NRID 1000090590266 en Takao, Seishin NRID 1000010614216 en Miyamoto, Naoki NRID 1000000552879 en Suzuki, Ryusuke NRID 1000000400052 en Sutherland, Kenneth NRID 1000030451446 en Kinoshita, Rumiko NRID 1000070507582 en Onimaru, Rikiya NRID 1000080374461 en Ishikawa, Masayori NRID 1000080314772 en Umegaki, Kikuo NRID 1000040643193 en Shirato, Hiroki NRID 1000020187537
Accessrights	open access
Rights	http://creativecommons.org/licenses/by/2.0/ en Creative Commons Attribution 2.0 Generic
Subject	Other en Spot-scanning proton therapy Other en Intensity-modulated radiation therapy Other en Hepatocellular carcinoma Other en Radiation induced liver disease NDC 492
Description	Abstract en Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.
Publisher	en BioMed Central
Date	Issued2013-03-05
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/52762
Relation	isIdenticalTo DOI https://doi.org/10.1186/1748-717X-8-48
Journal	PISSN 1748-717X en Radiation Oncology Volume Number8 Page Start48
File	fulltext 1748-717X-8-48.pdf 2.9 MB (application/pdf) Issued2013-03-05
Oaidate	2023-07-26