Back

Title
  • Neuroprotective function of DJ-1 in Parkinson's disease.
Creator

Ariga, Hiroyoshi

Takahashi-Niki, Kazuko

Kato, Izumi

Maita, Hiroshi

Niki, Takeshi

Iguchi-Ariga, Sanae M M

Description
Other
  • Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer's disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.
Date Issued 2013
Languageeng
NIItypejournal article
VersiontypeVoR
Identifier URI http://hdl.handle.net/2115/53697
Relation
  • isIdenticalTo PMID 23766857
  • isIdenticalTo DOI https://doi.org/10.1155/2013/683920
Journal
    • ISSN 1942-0994
    • Oxidative medicine and cellular longevity
    2013, 683920
File
Oaidate2017-10-15T15:00:00Z