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Title	en A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1.
Creator	en Kagawa, Hiroki en Shino, Yuka en Kobayashi, Daigo en Demizu, Syunsuke en Shimada, Masumi en Ariga, Hiroyoshi NRID 1000020143505 en Kawahara, Hiroyuki NRID 1000070291151
Accessrights	open access
Rights	http://creativecommons.org/licenses/by/3.0/ en Creative Commons Attribution 3.0 Unported
Subject	MeSH en Amino Acid Sequence MeSH en Animals MeSH en Cell Nucleus/metabolism MeSH en HeLa Cells MeSH en Humans MeSH en Kruppel-Like Transcription Factors/physiology MeSH en Mice MeSH en Mice, Inbred C3H MeSH en Molecular Sequence Data MeSH en Receptors, Cell Surface/chemistry MeSH en Receptors, Cell Surface/metabolism MeSH en Sequence Homology, Amino Acid MeSH en Signal Transduction MeSH en Subcellular Fractions/metabolism MeSH en Transcription, Genetic NDC 499
Description	Abstract en Patched 1 (Ptc1) is a polytopic receptor protein that is essential for growth and differentiation. Its extracellular domains accept its ligand, Sonic Hedgehog, while the function of its C-terminal intracellular domain is largely obscure.
Publisher	en PloS
Date	Issued2011-04-13
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/53698
Relation	isIdenticalTo DOI https://doi.org/10.1371/journal.pone.0018638 PMID 21533246
Journal	PISSN 1932-6203 en PloS one Volume Number6 Issue Number4 Page Starte18638
File	fulltext 207_Ariga_2011_PLoS_ONE.pdf 3.06 MB (application/pdf) Issued2011-04-13
Oaidate	2023-07-26