| Title |
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en
Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1.
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| Creator |
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| Accessrights |
open access |
| Subject |
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Other
en
DJ-1
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Other
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pyrroloquinoline quinone
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Other
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oxidative stress
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Other
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neurotoxity
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MeSH
en
Animals
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MeSH
en
Antioxidants/pharmacology
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MeSH
en
Ascorbic Acid/pharmacology
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MeSH
en
Blotting, Western
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MeSH
en
Cell Death/drug effects
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MeSH
en
Cell Survival/drug effects
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MeSH
en
Dose-Response Relationship, Drug
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MeSH
en
Female
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MeSH
en
Hydrogen Peroxide/antagonists & inhibitors
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MeSH
en
Hydrogen Peroxide/toxicity
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MeSH
en
Microtubule-Associated Proteins/drug effects
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MeSH
en
Microtubule-Associated Proteins/genetics
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MeSH
en
Microtubule-Associated Proteins/metabolism
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MeSH
en
Neurons/drug effects
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MeSH
en
Oxidants/antagonists & inhibitors
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MeSH
en
Oxidants/toxicity
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MeSH
en
Oxidation-Reduction
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MeSH
en
Oxidative Stress/drug effects
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MeSH
en
Oxidopamine/antagonists & inhibitors
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MeSH
en
Oxidopamine/toxicity
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MeSH
en
Pregnancy
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MeSH
en
Protein Binding
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MeSH
en
Pyrroles/pharmacology
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MeSH
en
Quinolines/pharmacology
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MeSH
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Rats
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MeSH
en
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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MeSH
en
Tetrazolium Salts
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MeSH
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Thiazoles
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MeSH
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Tumor Cells, Cultured
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MeSH
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Vitamin E/pharmacology
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NDC
499
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| Description |
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Abstract
en
Pyrroloquinoline quinone (PQQ) has been shown to play a role as an anti-oxidant in neuronal cells and prevent neuronal cell death in a rodent stroke model. DJ-1, a causative gene product for a familial form of Parkinson's disease, plays a role in anti-oxidative stress function by self-oxidation of DJ-1. In this study, the expression level and oxidation status of DJ-1 were examined in SHSY-5Y cells and primary cultured neurons treated with 6-hydroxydopamine (6-OHDA) or H(2)O(2) in the presence or absence of PQQ. The pI shift of DJ-1 to an acidic point, which was observed in SHSY-5Y cells treated with 6-OHDA, was inhibited by PQQ. TOF-MS analyses showed that while the level of a reduced form of DJ-1, one of the active forms of DJ-1, was decreased in SHSY-5Y cells treated with 6-OHDA or H(2)O(2), PQQ increased the level of the reduced form of DJ-1. These results suggest that PQQ prevents oxidative stress-induced changes in oxidative status of DJ-1. Therefore, the neuroprotective effects of PQQ on oxidative stress-induced neuronal death may be at least in part involved in increased level of an active form of DJ-1.
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| Publisher |
en
The Pharmaceutical Society of Japan
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
VoR |
| Identifier |
HDL
http://hdl.handle.net/2115/53726
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| Relation |
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isIdenticalTo
DOI
https://doi.org/10.1248/bpb.31.1321
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PMID
18591768
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| Journal |
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en
Biological & pharmaceutical bulletin
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Volume Number31
Issue Number7
Page Start1321
Page End1326
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| File |
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| Oaidate |
2023-07-26 |
