| Title |
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en
A Potential Pathogenic Factor fromMycoplasma hominisis a TLR2-Dependent, Macrophage-Activating, P50-Related Adhesin
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| Creator |
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| Accessrights |
open access |
| Rights |
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en
This is the pre-peer-reviewed version of the following article: FULL CITE, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/aji.12279/abstract;jsessionid=500DAAEB7BE065A3A9874F78C851B78C.f01t02
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| Subject |
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Other
en
Adhesin
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Other
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TLR2
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Other
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genital mycoplasmosis
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Other
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macrophage
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NDC
497
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| Description |
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Abstract
en
PROBLEM: Mycoplasma hominis has been implicated in many inflammatory conditions of the human urogenital tract in particular amniotic infections that lead to fetal and neonatal disease and pre-term labor. The mechanisms responsible are poorly defined. METHOD OF STUDY: Biochemical and immunological methods were used to extract, purify, and characterize an inflammatory component present in M. hominis. RESULTS: We isolated and purified to homogeneity a 40-kDa bioactive lipoprotein from M. hominis that was a potent TLR2-dependent, CD14-independent activator of the human THP-1 macrophage cell line. Homology searches of the N-terminal sequence revealed that 22 of the first 23 residues were identical to those seen for the phase-variable M. hominis p50 adhesin. The truncated P50t lipoprotein importantly retained its adhesive properties for human macrophages. CONCLUSION: The unique adhesin/macrophage activator may play a key role in M. hominis infections by triggering an inflammatory cytokine cascade.
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| Publisher |
en
Wiley-Blackwell
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| Date |
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| Language |
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| Resource Type |
journal article |
| Version Type |
SMUR |
| Identifier |
HDL
http://hdl.handle.net/2115/59366
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| Relation |
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isVersionOf
DOI
https://doi.org/10.1111/aji.12279
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PMID
24938999
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| Journal |
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PISSN
1046-7408
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EISSN
1600-0897
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NCID
AA10729786
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en
American Journal of Reproductive Immunology
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Volume Number72
Issue Number3
Page Start285
Page End295
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| File |
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| Oaidate |
2023-07-26 |
