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Title	en Suprabasin as a novel tumor endothelial cell marker
Creator	en Alam, Mohammad T. en Nagao-Kitamoto, Hiroko en Ohga, Noritaka NRID 1000040548202 en Akiyama, Kosuke NRID 1000010609100 en Maishi, Nako NRID 1000000632423 en Kawamoto, Taisuke en Shinohara, Nobuo NRID 1000090250422 en Taketomi, Akinobu NRID 1000070363364 en Shindoh, Masanobu NRID 1000020162802 en Hida, Yasuhiro NRID 1000030399919 en Hida, Kyoko NRID 1000040399952
Accessrights	open access
Rights	http://creativecommons.org/licenses/by-nc-nd/3.0/ en Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
Subject	Other en Angiogenesis Other en suprabasin Other en suprabasin signaling Other en tumor endothelial cell marker Other en tumor endothelial cells NDC 490
Description	Abstract en Recent studies have reported that stromal cells contribute to tumor progression. We previously demonstrated that tumor endothelial cells (TEC) characteristics were different from those of normal endothelial cells (NEC). Furthermore, we performed gene profile analysis in TEC and NEC, revealing that suprabasin (SBSN) was upregulated in TEC compared with NEC. However, its role in TEC is still unknown. Here we showed that SBSN expression was higher in isolated human and mouse TEC than in NEC. SBSN knockdown inhibited the migration and tube formation ability of TEC. We also showed that the AKT pathway was a downstream factor of SBSN. These findings suggest that SBSN is involved in the angiogenic potential of TEC and may be a novel TEC marker.
Publisher	en Wiley-Blackwell
Date	Issued2014-12
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/57895
Relation	isIdenticalTo DOI https://doi.org/10.1111/cas.12549
Journal	PISSN 1347-9032 en Cancer science Volume Number105 Issue Number12 Page Start1533 Page End1540
File	fulltext cas12549.pdf 1.96 MB (application/pdf) Issued2014-12
Oaidate	2023-07-26