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Title
  • en Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis
Creator
Accessrights open access
Rights
  • en This is the peer reviewed version of the following article: [Age-related alteration of expression and function of TLRs and NK activity in oral candidiasis], which has been published in final form at [10.1111/odi.12329]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Subject
  • Other en toll-like receptors
  • Other en natural killer cell activity
  • Other en oral candidiasis
  • NDC 497
Description
  • Abstract en ObjectiveRoles of aging or immune responses mediated by Toll-like receptors and natural killer cell in the onset or progression of human candidiasis remain unclear. This study was designed to elucidate the roles using peripheral blood mononuclear cells from healthy donors and patients with oral candidiasis. Subjects and methodsSubjects tested were healthy volunteers and patients who visited Dental Clinical Division of Hokkaido University Hospital. The patients with oral candidiasis included 39 individuals (25-89years of age) with major complaints on pain in oral mucosa and/or dysgeusia. Healthy volunteers include students (25-35years of age) and teaching staffs (50-65years of age) of Hokkaido University Graduate School of Dental Medicine. ResultsFunctions of Toll-like receptors 2 and 4 were downregulated significantly and the natural killer activity was slightly, but not significantly downregulated in aged healthy volunteers compared with healthy young volunteers. Functions of Toll-like receptors 2 and 4 and the natural killer activity were significantly downregulated in patients with oral candidiasis compared with healthy volunteers. ConclusionDownregulation of functions of Toll-like receptors 2 and 4 as well as natural killer activity is suggested to be associated with the onset or progression of oral candidiasis in human.
Publisher en Wiley-Blackwell
Date
    Issued2015-07
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/62349
Relation
  • isVersionOf DOI https://doi.org/10.1111/odi.12329
  • PMID 25704085
Journal
    • PISSN 1354-523X
    • EISSN 1601-0825
    • NCID AA11044105
      • en Oral diseases
      • Volume Number21 Issue Number5 Page Start645 Page End651
File
Oaidate 2023-07-26