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Title	en Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation : A Multicenter Retrospective Observational Study
Creator	en Hayakawa, Mineji NRID 1000010374282 en Kudo, Daisuke NRID 1000030455844 en Saito, Shinjiro en Uchino, Shigehiko en Yamakawa, Kazuma en Iizuka, Yusuke en Sanui, Masamitsu en Takimoto, Kohei en Mayumi, Toshihiko en Ono, Kota en Azuhata, Takeo en Ito, Fumihito en Yoshihiro, Shodai en Hayakawa, Katsura en Nakashima, Tsuyoshi en Ogura, Takayuki en Noda, Eiichiro en Nakamura, Yoshihiko en Sekine, Ryosuke en Yoshikawa, Yoshiaki en Sekino, Motohiro NRID 1000040380927 en Ueno, Keiko en Okuda, Yuko en Watanabe, Masayuki en Tampo, Akihito NRID 1000080531524 en Saito, Nobuyuki en Kitai, Yuya en Takahashi, Hiroki en Kobayashi, Iwao en Kondo, Yutaka en Matsunaga, Wataru en Nachi, Sho NRID 1000030452155 en Miike, Toru en Takahashi, Hiroshi en Takauji, Shuhei en Umakoshi, Kensuke en Todaka, Takafumi en Kodaira, Hiroshi en Andoh, Kohkichi en Kasai, Takehiko en Iwashita, Yoshiaki en Arai, Hideaki en Murata, Masato en Yamane, Masahiro en Shiga, Kazuhiro en Hori, Naoto
Accessrights	open access
Rights	https://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject	Other en antithrombin Other en coagulation abnormality Other en disseminated intravascular coagulation Other en mortality Other en sepsis NDC 490
Description	Abstract en Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits of AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed to clarify the effect of AT supplementation on sepsis-induced DIC using propensity score analyses. Data from 3,195 consecutive adult patients admitted to 42 intensive care units for severe sepsis treatment were retrospectively analyzed; 1,784 patients were diagnosed with DIC (n=715, AT group; n=1,069, control group). Inverse probability of treatment-weighted propensity score analysis indicated a statistically significant association between AT supplementation and lower in-hospital all-cause mortality (n=1,784, odds ratio [95% confidence intervals]: 0.748 [0.572-0.978], P=0.034). However, quintile-stratified propensity score analysis (n=1,784, odds ratio: 0.823 [0.646-1.050], P=0.117) and propensity score matching analysis (461 matching pairs, odds ratio: 0.855 [0.649-1.125], P=0.263) did not show this association. In the early days after intensive care unit admission, the survival rate was statistically higher in the propensity score-matched AT group than in the propensity score-matched control group (P=0.007). In DIC patients without concomitant heparin administration, similar results were observed. In conclusion, AT supplementation may be associated with reduced in-hospital all-cause mortality in patients with sepsis-induced DIC. However, the statistical robustness of this connection was not strong. In addition, although the number of transfusions needed in patients with AT supplementation increased, severe bleeding complications did not.
Publisher	en Lippincott Williams & Wilkins
Date	Issued2016-12
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/64275
Relation	isIdenticalTo DOI https://doi.org/10.1097/SHK.0000000000000727 PMID 27548460
Journal	PISSN 1073-2322 en SHOCK Volume Number46 Issue Number6 Page Start623 Page End631
File	fulltext Antithrombin_Supplementation_and_Mortality_in.4.pdf 406.44 KB (application/pdf) Issued2016-12 fulltext SHK_00_00_2016_08_08_HAYAKAWA_SHOCK-D-16-00228_SDC1.docx 33.19 KB (application/vnd.openxmlformats-officedocument.wordprocessingml.document) Issued2016-12
Oaidate	2023-07-26