Trends and determinant factors in the use of cardiac resynchronization therapy devices in Japan : Analysis of the Japan cardiac device treatment registry database

Yokoshiki Hisashi; Shimizu Akihiko; Mitsuhashi Takeshi; Furushima Hiroshi; Sekiguchi Yukio; Manaka Tetsuyuki; Nishii Nobuhiro; Ueyama Takeshi; Morita Norishige; Nitta Takashi; Okumura Ken

Title	en Trends and determinant factors in the use of cardiac resynchronization therapy devices in Japan : Analysis of the Japan cardiac device treatment registry database
Creator	en Yokoshiki, Hisashi NRID 1000040360911 en Shimizu, Akihiko en Mitsuhashi, Takeshi NRID 1000060275675 en Furushima, Hiroshi en Sekiguchi, Yukio NRID 1000090447251 en Manaka, Tetsuyuki en Nishii, Nobuhiro NRID 1000050537214 en Ueyama, Takeshi en Morita, Norishige en Nitta, Takashi NRID 1000040256954 en Okumura, Ken NRID 1000020185549
Accessrights	open access
Rights	http://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject	Other en Cardiac resynchronization therapy Other en Defibrillator Other en Primary prevention Other en Heart failure NDC 490
Description	Abstract en Background: The choice of cardiac resynchronization therapy device, with (CRT-D) or without (CRT-P) a defibrillator, in patients with heart failure largely depends on the physician's discretion, because it has not been established which subjects benefit most from a defibrillator. Methods: We examined the annual trend of CRT device implantations between 2006 and 2014, and evaluated the factors related to the device selection (CRT-D or CRT-P) for primary prevention of sudden cardiac death in patients with heart failure by analyzing the Japan Cardiac Device Treatment Registry (JCDTR) database from January 2011 and August 2015 (CRT-D, n=2714; CRT-P, n=555). Results: The proportion of CRT-D implantations for primary prevention among all the CRT-D recipients was more than 70% during the study period. The number of CRT-D implantations for primary prevention reached a maximum in 2011 and decreased gradually between 2011 and 2014, whereas CRT-P implantations increased year by year until 2011 and remained unchanged in recent years. Multivariate analysis identified age (odds ratio [OR] 0.92, 95% confidence interval [CI] 0.90-0.95, P < 0.0001), male sex (OR 1.99, 95% CI 1.28-3.11, P < 0.005), reduced left ventricular ejection fraction (LVEF) (OR 0.96, 95% CI 0.94-0.98, P < 0.0001), and non-sustained ventricular tachycardia (NSVT) (OR 2.85, 95% CI 1.87-4.35, P < 0.0001) as independent factors favoring the choice of CRT-D. Conclusions: Younger age, male sex, reduced LVEF, and a history of NSVT were independently associated with the choice of CRT-D for primary prevention of sudden cardiac death in patients with heart failure in Japan.
Publisher	en Elsevier
Date	Issued2016-12
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/64758
Relation	isIdenticalTo DOI https://doi.org/10.1016/j.joa.2016.04.002
Journal	PISSN 1880-4276 en Journal of arrhythmia Volume Number32 Issue Number6 Page Start486 Page End490
File	fulltext 1-s2.0-S1880427616300321-main.pdf 664.75 KB (application/pdf) Issued2016-12 fulltext SuppleFig1.tif 1.35 MB (image/tiff) Issued2016-12 fulltext mmc2.pdf 30.29 KB (application/pdf) Issued2016-12
Oaidate	2023-07-26