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Title	en Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016-2017 in Northern Japan
Creator	en Hiono, Takahiro en Okamatsu, Masatoshi NRID 1000000507163 en Matsuno, Keita NRID 1000040753306 en Haga, Atsushi en Iwata, Ritsuko en Nguyen, Lam Thanh en Suzuki, Mizuho en Kikutani, Yuto en Kida, Hiroshi NRID 1000010109506 en Onuma, Manabu en Sakoda, Yoshihiro NRID 1000040333637
Accessrights	open access
Rights	en This is the peer reviewed version of the following article: Characterization of H5N6 highly pathogenic avian influenza viruses isolated from wild and captive birds in the winter season of 2016–2017 in Northern Japan, which has been published in final form at https://doi.org/10.1111/1348-0421.12506. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Subject	Other en H5N6 Other en highly pathogenic avian influenza virus Other en wild bird
Description	Abstract en On 15 November 2016, a black swan that had died in a zoo in Akita prefecture, northern Japan, was strongly suspected to have highly pathogenic avian influenza (HPAI); an HPAI virus (HPAIV) belonging to the H5N6 subtype was isolated from specimens taken from the bird. After the initial report, 230 cases of HPAI caused by H5N6 viruses from wild birds, captive birds, and domestic poultry farms were reported throughout the country during the winter season. In the present study, 66 H5N6 HPAIVs isolated from northern Japan were further characterized. Phylogenetic analysis of the hemagglutinin gene showed that the H5N6 viruses isolated in northern Japan clustered into Group C of Clade 2.3.4.4 together with other isolates collected in Japan, Korea and Taiwan during the winter season of 2016-2017. The antigenicity of the Japanese H5N6 isolate differed slightly from that of HPAIVs isolated previously in Japan and China. The virus exhibited high pathogenicity and a high replication capacity in chickens, whereas virus growth was slightly lower in ducks compared with that of an H5N8 HPAIV isolate collected in Japan in 2014. Comprehensive analyses of Japanese isolates, including those from central, western, and southern Japan, as well as rapid publication of this information are essential for facilitating greater control of HPAIVs.
Publisher	en John Wiley & Sons
Date	Issued2017-08-16
Language	eng
Resource Type	journal article
Version Type	AM
Identifier	HDL http://hdl.handle.net/2115/71524
Relation	isVersionOf DOI https://doi.org/10.1111/1348-0421.12506 PMID 28815716
Journal	PISSN 0385-5600 en Microbiology and immunology Volume Number61 Issue Number9 Page Start387 Page End397
File	fulltext Revised Fig1 Hiono et al.tiff 24.4 MB (image/tiff) Issued2017-08-16 fulltext Revised Fig2 Hiono et al.tiff 24.4 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS1 Hiono et al.TIF 849.93 KB (image/tiff) Issued2017-08-16 fulltext Revised FigS2a Hiono et al.TIF 1.39 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS2b Hiono et al.TIF 1.54 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS2c Hiono et al.TIF 1.63 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS2d Hiono et al.TIF 1.54 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS2e Hiono et al.TIF 1.52 MB (image/tiff) Issued2017-08-16 fulltext Revised FigS2f Hiono et al.TIF 1.54 MB (image/tiff) Issued2017-08-16 fulltext Revised Main text Hiono et al.pdf 170.38 KB (application/pdf) Issued2017-08-16 fulltext Revised Table 2 Hiono et al.xlsx 12.73 KB (application/vnd.openxmlformats-officedocument.spreadsheetml.sheet) Issued2017-08-16 fulltext Table 1 Hiono et al.xlsx 12.63 KB (application/vnd.openxmlformats-officedocument.spreadsheetml.sheet) Issued2017-08-16 fulltext Table 1ctd Hiono et al.xlsx 12.7 KB (application/vnd.openxmlformats-officedocument.spreadsheetml.sheet) Issued2017-08-16 fulltext Table 3 Hiono et al.xlsx 11.35 KB (application/vnd.openxmlformats-officedocument.spreadsheetml.sheet) Issued2017-08-16
Oaidate	2023-07-26