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Title	en Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms : a report of three cases
Creator	en Hane, Yuma en Tsuchikawa, Takahiro NRID 1000050507572 en Tanaka, Kimitaka NRID 1000010758642 en Nakanishi, Yoshitsugu NRID 1000040447058 en Asano, Toshimichi NRID 1000010756688 en Noji, Takehiro NRID 1000010739296 en Kurashima, Yo NRID 1000040374350 en Ebihara, Yuma NRID 1000050632981 en Murakami, Soichi NRID 1000080706573 en Nakamura, Toru NRID 1000070645796 en Okamura, Keisuke NRID 1000090724401 en Takeuchi, Satoshi en Shichinohe, Toshiaki NRID 1000070374353 en Hirano, Satoshi NRID 1000050322813
Accessrights	metadata only access
Rights	https://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
Subject	Other en Neuroendocrine neoplasm Other en Endoscopic resection Other en Long-term follow-up Other en Recurrence NDC 490
Description	Abstract en Background Rectal neuroendocrine neoplasms (NENs) are rare, but their incidence has increased in recent years. The metastasis rate is low in cases of a tumor diameter < 1 cm or depth of invasion lower than the submucosa; therefore, the European Neuroendocrine Tumor Society (ENETS) and the North American Neuroendocrine Tumor Society (NANETS) consensus guidelines recommend endoscopic resection. Since little has been reported on the long-term prognosis of endoscopic resection for rectal NEN, consensus is lacking regarding the follow-up period after endoscopic resection. Case presentation Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) for rectal NEN. The pathological findings indicated a depth lower than the submucosa and complete radical resection in all cases and lymphovascular invasion in only one case. All three cases showed metachronous multiple liver metastases after 9-13 years of follow-up for EMR, despite achieving complete resection and without muscular invasion. Conclusions Metachronous liver metastases may occur after long interval following endoscopic resection; thus, long-term follow-up is necessary after endoscopic resection for rectal NEN.
Publisher	en Springer (SpringerOpen)
Date	Issued2020-01-15
Language	eng
Resource Type	journal article
Version Type	NA
Identifier	HDL http://hdl.handle.net/2115/76917
Relation	isIdenticalTo DOI https://doi.org/10.1186/s40792-020-0792-5 PMID 31940115
Journal	PISSN 2198-7793 en Surgical case reports Volume Number6 Issue Number1 Page Start22
Oaidate	2023-07-26