Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan

Hamaguchi Sanae; Tsuchihashi-Makaya Miyuki; Kinugawa Shintaro; Yokota Takashi; Takeshita Akira; Yokoshiki Hisashi; Tsutsui Hiroyuki; The JCARE-CARD Investigators

Title	en Anemia is an Independent Predictor of Long-Term Adverse Outcomes in Patients Hospitalized With Heart Failure in Japan
Creator	en Hamaguchi, Sanae en Tsuchihashi-Makaya, Miyuki en Kinugawa, Shintaro NRID 1000060399871 en Yokota, Takashi NRID 1000090374321 en Takeshita, Akira en Yokoshiki, Hisashi NRID 1000040360911 en Tsutsui, Hiroyuki NRID 1000070264017 en The JCARE-CARD Investigators
Accessrights	metadata only access
Rights	https://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject	Other en Anemia Other en Heart failure Other en Hemoglobin Other en Mortality Other en Prognosis NDC 490
Description	Abstract en Background: Anemia is common in patients with heart failure (HF) and is associated with worse outcomes. However, the effects of anemia are unknown in an unselected group of HF patients encountered in routine clinical practice in Japan. The impact of anemia on long-term outcomes including mortality and rehospitalization among patients hospitalized with HF was thus assessed. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of patients hospitalized with worsening HF and the outcomes were followed. Study cohorts (n=1,960) were classified into 4 groups by discharge hemoglobin quartiles: <10.1 g/dl (n=482), 10.1-11.9 g/dl (n=479), 12.0-13.6 g/dl (n=487), and ?13.7 g/dl (n=512). Of the total cohort of HF patients, 57% had anemia, defined by using the World Health Organization definition. Patients with lower hemoglobin quartiles had higher rates of all-cause death, cardiac death, and rehospitalization due to worsening HF. After multivariable adjustment, the risk for all-cause death, cardiac death, and rehospitalization significantly increased with low hemoglobin concentrations. Conclusions: Anemia was quite common especially in patients with HF encountered in routine clinical practice in Japan, and lower hemoglobin was independently associated with long-term adverse outcomes in these patients. (Circ J 2009; 73: 1901-1908)
Publisher	en The Japanese Circulation Society ja 社団法人日本循環器学会
Date	Issued2009
Language	eng
Resource Type	journal article
Version Type	NA
Identifier	HDL http://hdl.handle.net/2115/76967
Relation	isIdenticalTo DOI https://doi.org/10.1253/circj.CJ-09-0184
Journal	PISSN 1346-9843 EISSN 1347-4820 en Circulation Journal Volume Number73 Issue Number10 Page Start1901 Page End1908
Oaidate	2023-07-26