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Title
  • en Beta-Blocker Use at Discharge in Patients Hospitalized for Heart Failure Is Associated With Improved Survival
Creator
    • en Tsuchihashi-Makaya, Miyuki
    • en Hamaguchi, Sanae
    • en Goto, Daisuke
    • en Goto, Kazutomo
    • en Takeshita, Akira
    • en The JCARE-CARD Investigators
Accessrights metadata only access
Rights
Subject
  • Other en β-blocker
  • Other en Heart failure
  • Other en Outcome
  • Other en Re-admission
  • Other en Surviva
  • NDC 490
Description
  • Abstract en Background: Previous studies demonstrated thatβ-blocker use at the time of hospital discharge significantly increased postdischarge treatment rates, associated with an early (60- to 90-day) survival benefit in patients with heart failure (HF). However, it is unknown whether this therapeutic approach can also improve the long-term survival. We thus examined the long-term effects ofβ-blocker use at discharge on outcomes in patients hospitalized for HF and left ventricular systolic dysfunction (LVSD) (ejection fraction <40%). Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) enrolled HF patients hospitalized with worsening symptoms and they were followed during an average of 2.2 years. A total of 947 patients had LVSD, among whom 624 (66%) were eligible to receive aβ-blocker at discharge. After adjustment for covariate and propensity score, discharge use ofβ-blocker, when compared to noβ-blocker use, was associated with a significant reduced risk of all-cause mortality (hazard ratio (HR) 0.564, 95% confidence interval (CI) 0.358-0.889, P=0.014) and cardiac mortality (HR 0.489, 95%CI 0.279-0.859, P=0.013) after hospital discharge. Conclusions: Beta-blocker use at the time of discharge was associated with a long-term survival benefit in a diverse cohort of patients hospitalized with HF. (Circ J 2010; 74: 1364-1371)
Publisher en The Japanese Circulation Society ja 社団法人 日本循環器学会
Date
    Issued2010
Language
  • eng
Resource Type journal article
Version Type NA
Identifier HDL http://hdl.handle.net/2115/76969
Relation
  • isIdenticalTo DOI https://doi.org/10.1253/circj.CJ-09-0993
Journal
    • PISSN 1346-9843
    • EISSN 1347-4820
      • en Circulation Journal
      • Volume Number74 Issue Number7 Page Start1364 Page End1371
Oaidate 2023-07-26