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Title
  • en Altered Renal Pathology in an Autoimmune Disease Mouse Model After Induction of Diabetes Mellitus
Creator
Accessrights open access
Rights
  • en This article has been published in a revised form in [Microscopy Society of America] [http://doi.org/10.1017/S143192762100057X]. This version is published under a Creative Commons CC-BY-NC-ND. No commercial re-distribution or re-use allowed. Derivative works cannot be distributed. ©[ The Author(s)].
  • https://creativecommons.org/licenses/by-nc-nd/4.0/
  • en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Subject
  • Other en autoimmune disease
  • Other en BXSB
  • Other en MpJ-Yaa
  • Other en diabetes mellitus
  • Other en diabetic kidney disease
  • Other en streptozotocin
  • NDC 490
Description
  • Abstract en Diabetes mellitus (DM) is a predisposing factor for renal disorder progression and is referred to as diabetic kidney disease (DKD). However, there are no reports of DKD with an underlying autoimmune disorder. In this study, we compared the pathophysiological changes caused by DM induction after streptozotocin (STZ) injection in comparison with that in a control group receiving citrate buffer (CB) in the autoimmune disease model mice "BXSB/MpJ-Yaa" (Yaa) and the wild-type strain BXSB/MpJ. Both strains showed hyperglycemia after 12 weeks of STZ injection. Interestingly, the Yaa group developed membranous and proliferative glomerulonephritis, which tended to be milder glomerular lesions in the STZ group than in the CB group, as indicated by a decreased mesangial area and ameliorated albuminuria. Statistically, the indices for hyperglycemia and autoimmune abnormalities were negatively and positively correlated with the histopathological parameters for mesangial matrix production and glomerular proliferative lesions, respectively. STZ treatment induced renal tubular anisonucleosis and dilations in both strains, and they were more severe in Yaa. Significantly decreased cellular infiltration was observed in the Yaa group compared to the CB group. Thus, in DKD related to autoimmune nephritis, hyperglycemia modifies its pathology by decreasing the mesangial area and interstitial inflammation and aggravating renal tubular injury.
Publisher en Cambridge University Press
Date
    Issued2021-08
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/84019
Relation
  • isVersionOf DOI https://doi.org/10.1017/S143192762100057X
Journal
    • PISSN 1431-9276
      • en Microscopy and microanalysis
      • Volume Number27 Issue Number4 Page Start897 Page End909
File
Oaidate 2023-07-26