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Title
  • en The CYP1D subfamily of genes in mammals and other vertebrates.
Creator
Accessrights open access
Rights
  • en The original publication is available at www.springerlink.com
Subject
  • NDC 467
Description
  • Abstract en Members of the cytochrome P450 family 1 (CYP1s) are involved in the detoxification and bioactivation of numerous environmental pollutants and phytochemicals, such as polycyclic aromatic hydrocarbons (PAHs), aromatic amines and flavonoids. The vertebrate CYP1 gene comprises four subfamilies, CYP1A, CYP1B, CYP1C and CYP1D. Recently, the CYP1D gene was identified in fish, and subsequently in the platypus. These findings indicate the possibility that all vertebrates have a functional CYP1D subfamily. However, there is no information on the mammalian CYP1D gene. In this study, we investigated the genomic location of CYP1D genes in mammals and other vertebrates in silico. We also performed phylogenetic analysis and calculated the identities and similarities of CYP1D sequences. The data from synteny and phylogenetic analyses of CYP1D genes demonstrated the evolutionary history of the CYP1 gene family. The results suggested that CYP1D became a non-functional pseudogene in human and bovine species; however, several other mammals possess functional CYP1D genes. The promoter regions of CYP1D genes were also examined. Unlike other CYP1 isoforms, few xenobiotic responsive element (XRE)-like sequences were found upstream of the CYP1D genes. Analysis of mammalian CYP1Ds also provided new insight into the relationship between CYP1 genes and the aryl hydrocarbon receptor.
Publisher en Springer
Date
    Issued2010-06
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/45756
Relation
  • isVersionOf DOI https://doi.org/10.1007/s00335-010-9263-9
  • PMID 20495808
Journal
    • PISSN 0938-8990
    • NCID AA10839514
      • en Mammalian Genome
      • Volume Number21 Issue Number5-6 Page Start320 Page End329
File
Oaidate 2023-07-26