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Title	en Correlation between Pupil Size and Subjective Passage of Time in Non-Human Primates
Creator	en Suzuki, Tomoki W. en Kunimatsu, Jun NRID 1000050632395 en Tanaka, Masaki NRID 1000090301887
Accessrights	open access
Rights	https://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
Subject	Other en eye movements Other en monkeys Other en pupil diameter Other en self-timing Other en temporal processing NDC 490
Description	Abstract en Our daily experience of time is strongly influenced by internal states, such as arousal, attention, and mood. However, the underlying neuronal mechanism remains largely unknown. To investigate this, we recorded pupil diameter, which is closely linked to internal factors and neuromodulatory signaling, in monkeys performing the oculomotor version of the time production paradigm. In the self-timed saccade task, animals were required to make a memory-guided saccade during a predetermined time interval following a visual cue. We found that pupil diameter was negatively correlated with trial-by-trial latency of self-timed saccades. Because no significant correlation was found for visually guided saccades, correlation of self-timed saccades could not be explained solely by the facilitation of saccade execution. As the reward amount was manipulated, pupil diameter and saccade latency altered in opposite directions and the magnitudes of modulation correlated strongly across sessions, further supporting the close link between pupil diameter and the subjective passage of time. When the animals were trained to produce two different intervals depending on the instruction, the pupil size again correlated with the trial-by-trial variation of saccade latency in each condition; however, pupil diameter differed significantly for saccades with similar latencies generated under different conditions. Our results indicate that internal brain states indexed by pupil diameter, which parallel noradrenergic neuronal activity (Aston-Jones and Cohen, 2005), may bias trial-by-trial variation in the subjective passage of time.
Publisher	en Society for Neuroscience
Date	Issued2016-11-02
Language	eng
Resource Type	journal article
Version Type	VoR
Identifier	HDL http://hdl.handle.net/2115/65200
Relation	isIdenticalTo DOI https://doi.org/10.1523/JNEUROSCI.2533-16.2016 PMID 27807173
Journal	PISSN 0270-6474 en Journal of neuroscience Volume Number36 Issue Number44 Page Start11331 Page End11337
File	fulltext 11331.full.pdf 689.51 KB (application/pdf) Issued2016-11-02
Oaidate	2023-07-26